Collaborative health projects
Bringing advanced bioinformatics to clinical studies to understand how humans and their microbes interact in health and disease.
Explore our health projects →Microbiome · Bioinformatics · Human health
Langille Lab
Better methods for microbiome science, applied to human health.
We develop and test bioinformatic methods to understand the role of the microbiome in disease, and we partner with clinical and basic scientists to put them to work.
What we do
Read more about our research →Methods and resources
Creating and validating bioinformatic approaches that get more reliable biological insight out of microbiome data.
See our software →Integrated Microbiome Resource
A sequencing and bioinformatics service housed in the lab, supporting microbiome researchers around the world.
Visit imr.bio →Open software
Tools and workflows we build and maintain for the microbiome community. All are free and open source.
PICRUSt2
Predicts the functional potential of a microbial community from marker gene sequences.
Microbiome Helper
Standard operating procedures, tutorials and workflows for amplicon and metagenomic analysis.
GeCoCheck
Confirms which species in a Kraken classification are real by checking how much of each reference genome the assigned reads cover.
POMS
Links shifts in microbial functions to the lineages that carry them in metagenomic data.
FuncDiv
Computes contributional diversity of joint taxa and function data from microbiome studies.
JarrVis
Interactive views of which taxa drive differences in predicted functions.
- Technical replicates and multiple sequencing approaches reveal weak and inconsistent microbiome signals in lung tumour and blood samples from patients with lung cancer
- Population-based characterisation of child and adolescent oral bacterial microbiomes
- From classification to confirmation: Verification of metagenomic taxonomic classifications through mapping of classified reads to reference genomes
- Effect of bedrest on the human gut and oral microbiome: implications for frailty
Join the lab
We welcome trainees from many backgrounds and disciplines. If you want to build skills in genomics and bioinformatics while working on real health questions, we would like to hear from you.
Sequencing service
Need microbiome sequencing?
The Integrated Microbiome Resource offers amplicon and metagenomic sequencing with bioinformatics support, for academic and industry researchers.